Set:	50tabs
Price:	$170.00

Tilidine is an opioid analgesic used similarly to MORPHINE in the control of moderate to severe pain. Tilidine is used in severe pains related to malignant diseases; spastic states, associated with severe pain originating from the gastrointestinal tract, urinary and biliary tracts; postoperative pain, neuralgia, and particularly neuralgia of the trigeminal nerve.

Tilidine is a synthetic narcotic analgesic agent of the group of phenylaminocyclohexanes. It exerts powerful analgesic action against different types of pain. Generally, the efficiency of the drug in extero- and proprioceptive pain is higher compared to the nonnarcotic analgesics. Its analgesic activity, as well as a number of other effects, is related to the activation of specific opioid receptors in the central nervous system, which regulate anti-nociception. It also exerts a spasmolytic action.

Special precautions

• Tilidine is contra-indicated in patients with a history of hypersensitivity to this drug.
  
• It should not be used in conditions in which an increase in intracranial pressure may be dangerous.
  
• Tilidine should not be used in the management of head injuries, acute alcoholism, after operations on the biliary tract, and in the presence of cyanosis or other significant disturbances of respiratory function.
  
• Tilidine should not be used in the presence of myocardial ischaemia.
  
• Contra-indicated in porphyria.
  
• Contra-indicated in patients being treated with monoamine oxidase inhibitors or within 14 days of discontinuing such treatment.
  
• Safety in pregnancy and lactation has not been established.

Tilidine should be used in lower doses in patients with kidney diseases, because the elimination is disturbed. In acute myocardial infarction patients, it must be used cautiously. Alcohol should be avoided during the treatment with this drug.

Side effects

• Tilidine hydrochloride may cause nausea, vomiting, constipation, drowsiness, confusion, dry mouth, sweating, facial flushing, vertigo, bradycardia, palpitations, orthostatic hypotension, hypothermia, restlessness, changes of mood and miosis. Micturition may be difficult and there may be ureteric or biliary spasm. Raised intracranial pressure may occur. Reactions such as urticaria and pruritus may occur.
  
• Tilidine hydrochloride should be given with caution to patients with hypothyroidism, adrenocortical insufficiency, impaired liver function, prostatic hypertrophy or shock. It should be used with caution in patients with inflammatory or obstructive bowel disorders. The dosage should be reduced in elderly and debilitated patients.
  The administration of Tilidine hydrochloride during labour may cause respiratory depression in the new-born infant.
  
• The depressant effects of Tilidine hydrochloride are enhanced by depressants of the central nervous system such as alcohol, anaesthetics, hypnotics and sedatives, and neuroleptics such as phenothiazines.
  
• Tilidine hydrochloride is subject to abuse and drug dependence may develop especially after repeated administration. Contact dermatitis has been reported.
  
• Patients taking Tilidine should not drive motor vehicles, operate machinery or drink alcoholic beverages. In patients with impaired kidney function it might be advisable to reduce the tilidine dose.

For more information about any other possible risks associated with this medicine, please read the information provided with the medicine or consult your doctor or pharmacist.

Take all appointments with your doctor.

Don't let anyone else take your medicines.